Duties

• Support genomic biomarker profiling studies in oncology clinical trials
• Integrative analyses of omics data and clinical variables to test and discover biomarkers for response and resistance to therapy
• Develop and implement analytical tools with emphasis on translational implications for clinical genomics
• Communicate key findings and biological context to clinical trial teams, research teams, and key stakeholders

Duties

• Execute in-depth literature research, data collection, management and analysis, screened data as requested by client
• Convey complex technical insights and create detailed reports based on research findings to clients
• Attention to detail and ability to manage multiple projects and priorities
• Collaborate with consultant team to ensure client’s objectives are met

Project aims

• Gain an understanding of interactions between the environment and cancer genomics by integrating genomic data and molecular biology within human studies of cancer pathogenesis and progression
• Determine effects of genomic alterations, and develop/discover genomic determinants of response to therapy
• Develop DNA repair classifiers in the TCGA using gene expression data and machine learning strategies including hierarchal clustering
• Evaluate associations with race, ethnicity, and ancestry in a community-centered ELSI framework, and consider ways to mediate bias in models to improve precision medicine initiatives in historically excluded populations

Project aims

• Generation of broader repertoire Epstein-Barr virus(EBV)-specific T cells for EBV+ lymphomas
• Construction of constitutive cytokine receptor that potentially improves proliferation, survival, and anti-tumor activity of genetically modified T cells during repeated exposure to tumor cells

Project Two: A 3D Model to Study Tumor Dormancy

• Used biomimetic PEG-based hydrogels ranging in stiffness for encapsulation and long-term 3D culture of breast cancer cells
• Investigated cancer cell behavior and disease progression within 3D hydrogel scaffolds

Project One: Creation of hADMSC Line Stably Expressing FRET-based Vinculin Tension Sensor

• Compared efficacy of two nonviral transfection techniques
• Visualized tension across cells using a FRET-based tension sensor