Discovering determinants of response to PD-1 inhibition in the BBN963 bladder cancer model.

May 6, 2019 8:00 AM
UNC Chapel Hill

BBN963 model exhibited mixed response to aPD1 in both experiments, gene expression profiling revealed differences in response between the two groups which allowed us to evaluate differences in tumor immune microenvironment between responders and non-responders, previous evaluation of cytokine/chemokine signaling revealed IL-1, IL-2, MIP-1a, RANTES is upregulated in responders, and IL-5 downregulated in non-responders, More recent studies I have completed shown that IL12 is upregulated in NR.

Markia Smith
Markia Smith
Doctoral Student

My work uses integrative genomic approaches to study environmental and genetic determinants of cancer, leading to health disparities.